2008년 11월 30일

Dr.Kim's Nanobiotechnology & Liposomal Nanoencapsulated Nanofood

@Dr. Kim's Liposomal Nanofood


The relation between biology and molecular nanotechnology can be denoted as molecular biology. The last few decennia developments in this area led to new therapeutical strategies which will be applied in treatment of human diseases. Delivering medicines on the right place in a human body is possible, thanks to the growing understanding of cellular recognition and transport mechanisms.
At the moment there is an approach that stands in the interest, called encapsulation of medicines or DNA. The encapsulation takes place in the double layer membrane capsule (liposome), so that the contents are protected against affection of the metabolism of a patient.
Liposomes were discovered about 30 years ago by A. Bangham and since then they became very versatile tools in biology, biochemistry and medicine.
[Structure of a liposome]
Liposomes are small artificial vesicles, which can be produced from natural phospholipids and cholesterol. The vesicles can be used as drug carriers and loaded with a great variety of molecules, such as small drug molecules, proteins, nucleotides and even plasmids. Liposomes are extremely versatile and due to the variability of their composition they can be used for a large number of applications.
The most important application is the delivery of medicines (anti-cancer remedies) at the right cells in a human body, also called encapsulation.
A special method, known as ‘black hole loading’ is used for the encapsulation of medicines. This method is based on creating different environments within and outside a liposome. The liposomes are prepared in a solution that creates the inner environment, after which this solution is replaced by a solution which contains the medicine. Further the solution has to be heated, so that the solution which contains the medicine enters the liposome via the membrane. When it reaches the liposome it forms a crystalline product. This means that the molecules are arranged regularly.
The method “Black hole loading” depends on the composition of the enveloped membrane and especially of the specific ligands which are attached at the outer layer of the membrane. A ligand is a cellular substance that binds to other molecules, like receptors in the human body.
The structure of the outer layer is of special interest. There are a few qualities which the structure of the outer layer needs to posses, so that the encapsulation of the medicine is at the right place in the human body. These qualities are:
- It has to protect the charge of the membrane, so that the particle can move through the body.
- It has to be sure that there is not an interaction between the blood of blood vessels and the charge of the membrane. At this way the particle can reach its destination.
- Once the particle reaches its destination, it has to recognise it, attach to it and deliver its charge.
The encapsulation can take place when the structure of the membrane posses these qualities. However the immune system of the human body normally neutralises the liposomes once they are injected in the blood vessel. The immune system recognises these liposomes as outsiders, so it tries to ‘destroy’ it. Because it takes time to reach its destination, it is possible that the immune systems ‘destroys’ the liposomes when they have not yet reached its destination.
Once this neutralisation of the human body can be decreased, the circulation time in the human body is increased, and so the delivering system is efficient.
Scientists think that they have a solution for this problem. They have increased the circulation time of the liposomes by building in a double layer fat molecule. This fat molecule is a polyethylene-glycol group (PEG) connected to a polar leading group.

This increasing circulation time is obtained by the sterical rejection of the PEG. The PEG forms an obstacle against the unwanted removing of the liposomes.

Furthermore it is possible to connect the ligands to the PEG, so that they are built in the outer layer of the membrane, in which the medicines with charged liposomes lay. This strategy, with a specific molecular interaction, makes it possible to adjust (with medicines charged) liposomes on the individual type of cancer of the patient.
[Chemical structure of Polyethylene-glycol group]

Fat-molecules can also form complexes with DNA. In contrast to a complex with liposomes, this development is still in the experimental phase.

There have been experiments done on animals. However, the results are disappointing. The DNA-complexes are ‘destroyed’ by the immune system immediately when they are injected. Now scientists are searching for molecules which are more compact. The DNA-complexes have to be small enough to prevent the closing off of capillaries.

The applications of fat-molecules with DNA will mainly be corrections in cell structures, which mean they are less related to the whole organism. Before we can even think about applications, there have to be done a lot of research on animals, and maybe later on humans.
As said before, this development is still in the beginning area. The next generations of DNA-complexes will probably contain newer and better methods for the encapsulation of medicines in human bodies.
Dr. Kim's Liposomal Nanoncapsulated Multivitamin for Nanofood is formulated by Dr. Dong-Myung Kim specifically for everybody aged 18 - 50 and contains Calcium plus 600 mg of Vitamin D as highly absorbable nano-particles along with Vitamin K, Magnesium, Manganese and the antioxidant power of Beta Carotene and Vitamin C to keep bones healthy and to protect you from osteoporosis. This targeted women's formula also contains Zinc as highly absorbable nano-particles to maintain immune function (which is extremely important for a busy woman constantly on the go!); iron to protect against fatigue and iron deficiency due to blood loss during menstruation; high levels of B vitamins, Korean Ginseng and 4 super absorbable mineral triturates to support energy and metabolism; the antioxidant power of Resveratrol and Green Tea to keep your skin healthy and glowing; Ginkgo Biloba to keep you feeling sharp, plus much more!!!
Dr. Kim's Nanofood is the foundation of any supplement regimen, therefore it is important to choose the right one for your specific needs for better health. INRS (International Nanofood Research Society, president Dr. Dong-Myung Kim) recognizes the different nutritional needs of individuals as they go through their life stages, from a newborn to a senior citizen. Gender, stress levels, age and exercise all affect your nutritional status and your supplementation should answer to these differences.
Dr. Kim's Liposomal Nanoncapsulated Multivitamin makes it easy for individuals to choose their own multi-vitamin based on their bionanotechnological make-up as well as their own personal goals. All formulas include highly absorbable active coenzyme forms of B vitamins and bisglycinate forms of minerals, plus digestive enzymes for optimal absorption. Oriental herbal bases are included in all formulas along with an emphasis on protective antioxidants for increased immune protection. Different formulas are available in pill, capsule, liquid and chewable forms to meet any preference.
Truescience™ ~♡

by nanofood | 2008/11/30 23:32 | ◑NanoScience | 트랙백 | 덧글(0)

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